Senior Scientists

Mari Kaunisto, PhD

Mikko Kallela, MD, PhD, Docent, Co-PI

Ville Artto, MD, PhD

Graduate Students

Marjo Hiekkala, MSc

Salli Vepsäläinen, MD

Staff

Leena Leikas, Research Nurse

Kallela M, Wessman M, Färkkilä, M, Palotie A, Koskenvuo M, Honkasalo, M-L, Kaprio J: Clinical characteristics of migraine in a population-based twin sample: differences in headache between migraine with and without aura. Cephalalgia, 19:151-158, 1999.

Wessman M, Kallela M, Kaunisto M, Marttila P, Sobel E, Hartiala J, Oswell G, Leal S, Papp J, Hämäläinen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor R, Zwart J-A, Ilmavirta M, Havanka H, Färkkilä M, Peltonen L, Palotie A. A Susceptibility Locus for Migraine with Aura, on Chromosome 4q24. Am J Hum Genet 70:652-662, 2002

Kaunisto MA, Harno H,Vanmolkot,KRJ.,Gargus JJ, Sun G, Liukkonen E, Kallela M,Van Den Maagdenberg AMJM, Frants RR, Palotie A, Färkkilä M, Wessman M. A novel missense ATP1A2 mutation in a large Finnish family with familial hemiplegic migraine type 2. Neurogenetics 5: 141-146, 2004

Anttila V, Kallela M, Oswell G, Kaunisto M, Nyholt D, Hämäläinen E, Terwilliger J, Sobel E, Kaprio J, Färkkilä M, Wessman M, Palotie A. Trait component analysis of migraine families reveals two new loci. Am J Hum Genet 79: 85-99, 2006

Anttila V, Nyholt DR, Kallela M, Artto V, Vepsäläinen S, Wennerström A, Tikka-Kleemola P, Kaunisto MA, Hämäläinen E, Widén E, Terwilliger J, Merikangas K, Montgomery DW, Martin NG, Kaprio J, Peltonen L, Färkkilä M, Wessman M, Palotie A. Chromosome 10q21-q23 – a consistently replicating locus for migraine. Am J Hum Genet, 82(5):1051-1063, 2008

Tikka-Kleemola P, Artto V, Vepsäläinen S, Sobel E, Räty S, Kaunisto MA, Anttila V, Hämäläinen E, Sumelahti M-L, Ilmavirta M, Färkkilä M, Kallela M, Palotie A, Wessman M. A visual migraine aura locus maps to 9q21-q22. Neurology 74(15):1171-1177, 2010

Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, Nyholt DR, Dimas AS, Freilinger T, Müller-Myhsok B, Artto V, Inouye M, Alakurtti K, Kaunisto MA, Hämäläinen E, de Vries B, Stam AH, Weller CM, Heinze A, Heinze-Kuhn K, Goebel I, Borck G, Göbel H, Steinberg S, Wolf C, Björnsson A, Gudmundsson G, Kirchmann M, Hauge A, Werge T, Schoenen J, Eriksson JG, Hagen K, Stovner L, Wichmann HE, Meitinger T, Alexander M, Moebus S, Schreiber S, Aulchenko YS, Breteler MM, Uitterlinden AG, Hofman A, van Duijn CM, Tikka-Kleemola P, Vepsäläinen S, Lucae S, Tozzi F, Muglia P, Barrett J, Kaprio J, Färkkilä M, Peltonen L, Stefansson K, Zwart JA, Ferrari MD, Olesen J, Daly M, Wessman M, van den Maagdenberg AM, Dichgans M, Kubisch C, Dermitzakis ET, Frants RR, Palotie A; International Headache Genetics Consortium. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet 42(10):869-873, 2010

Polvi A, Siren A, Kallela M, Rantala H, Artto V, Sobel EM, Palotie A, Lehesjoki AE, Wessman M. Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-24.3. Neurology, 78(3):202-209, 2012

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I,Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM,Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M,Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM,Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Göbel H,Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J,Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M,Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG,Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA,Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A; North American Brain Expression Consortium; UK Brain Expression Consortium; International Headache Genetics Consortium. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet 45(8):912-917, 2013

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH, Lehtimäki T, Sarin AP, Wedenoja J, Hinds DA, Buring JE, Schürks M, Ridker PM, Hrafnsdottir MG, Stefansson H, Ring SM, Hottenga JJ, Penninx BW, Färkkilä M, Artto V, Kaunisto M, Vepsäläinen S, Malik R, Heath AC, Madden PA, Martin NG, Montgomery GW, Kurki MI, Kals M, Mägi R, Pärn K, Hämäläinen E, Huang H, Byrnes AE, Franke L, Huang J, Stergiakouli E, Lee PH, Sandor C, Webber C, Cader Z, Muller-Myhsok B, Schreiber S, Meitinger T, Eriksson JG, Salomaa V, Heikkilä K, Loehrer E, Uitterlinden AG, Hofman A, van Duijn CM, Cherkas L, Pedersen LM, Stubhaug A, Nielsen CS, Männikkö M, Mihailov E, Milani L, Göbel H, Esserlind AL, Christensen AF, Hansen TF, Werge T; International Headache Genetics Consortium, Kaprio J, Aromaa AJ, Raitakari O, Ikram MA, Spector T, Järvelin MR, Metspalu A, Kubisch C, Strachan DP, Ferrari MD, Belin AC, Dichgans M, Wessman M, van den Maagdenberg AM, Zwart JA, Boomsma DI, Smith GD, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet 48(8):856-866, 2016

Folkhälsan Research Foundation

EVO Governmental Grants

European Commission

The Academy of Finland

Medicinska Understödsföreningen Liv och Hälsa (“Life and Health Medical Fund”)

Prof. Markus Färkkilä, Helsinki University Central Hospital, Helsinki, Finland

Prof. Aarno Palotie, Institute for Molecular Medicine Finland (FIMM) and Broad Institute of MIT and Harvard, Cambridge, USA/Head of the International Headache Genetics Consortium

Prof. Jaakko Kaprio, FIMM, Helsinki, Finland

Prof. John-Anker Zwart, Oslo University Hospital, Norway

Prof. Dale Nyholt, Queensland University of Technology, Australia

Prof. Arn van den Maagdenberg, Leiden University Medical Center, the Netherlands/coordinator of the EUROHEADPAIN Consortia

Prof. Eric Sobel, UCLA, Los Angeles, USA

Dr. Tero Hiekkalinna, National Institute for Health and Welfare (THL), Helsinki, Finland